Researchers watch in real time as fat-encased drug nanoparticles invade skin cells

said braka 10:12 PM
A University of Colorado Cancer Center study published

today in the journal ACS Nano describes the use of cutting-edge microscopy technology to visualize how  escape from  into surrounding  in a living mouse, offering clues that may help researchers design better  - both to keep dangerous drugs from accumulating in  cells and, oppositely, to take better advantage of this side-effect to specifically deliver drugs to these cells when needed.
"We know about the dose-limiting side-effects of liposomes, but no one had looked at what happens to the liposome over time in the skin - how they get there and what happens to liposomes after injection," says Dmitri Simberg, PhD, investigator at the CU Cancer Center and the paper's senior author.
For the current study, working in the CU Cancer Center Advanced Light Microscopy Core, co-authors Dominik Stitch, PhD, and Radu Moldovan, PhD, implemented a new technique known intravital multiphoton in vivo microscopy that enabled the team to watch fluorescent-tagged liposomes in real-time after injection. Very basically, liposomes would glow and the team would watch them.
"Surprisingly, we saw that even liposomes with a  meant to make them invisible to the immune system start exiting blood capillaries and sticking to skin cells within five minutes of injection," Simberg says. "Around three hours, we saw many skin cells loaded with liposomes and even seven days after injection, liposomes were still visible in the skin."


Read more at: https://phys.org/news/2017-10-real-fat-encased-drug-nanoparticles-invade.html#jCp